The role of methylation in silencing of TU3A expression in human cancers like renal, bladder, cervical, breast, hepatic, ovarian, and testicular cancer cells was studied by Awakura et al. They examined the RCC cell lines of Caki-1, ACHN, and NC65 and found that ACHN had low expression of TU3A while the other two did not show any expression. This evidence concerns the gene FAM107A and renal cell carcinoma.