HLA-G and neoplasm: Apart from restoring the expression of the above mentioned tumor suppressor genes in RCC, hypomethylating agents may also increase the expression of a few (four known) tumor promoter genes, namely Interleukin-8, which promotes angiogenesis and metastasis [77]; HLA-G, which is known to help tumor cells evade immunosurveillance [78]; G250, which produces bicarbonate and neutralizes the surrounding acidic pH and aids cancer progression [79]; and CYTIP, which helps tumor cells evade cell death cytokines [80].