Many randomized controlled trials (RCTs) have shown that antihypertensive (BP lowering) medications, including thiazide diuretics, beta blockers, and angiotensin-converting enzyme (ACE) inhibitors, reduce the risk of developing CVD, coronary heart disease (CHD), stroke, and other vascular events and mortality10, 11, 12, 13. This evidence concerns the gene ACE and Stroke.