Thus, compared with the wild-type sequence, mutant (G549A) GAS5 lncRNA is unable to riborepress androgen-mediated induction of several androgen target genes in prostate cancer cells, and its ability to induce apoptosis is either abolished (in prostate and breast cancer cell lines) or attenuated (lymphoid cell lines) [16]. The gene discussed is GAS5; the disease is breast carcinoma.