To reveal the epigenetic status of CLDN11 in malignant melanoma (MM) cell lines, we have analyzed its aberrant methylation in buf1280, C8161, IGR1, MeWo, SKMEL13, SKMEL28, lung cancer (A549), cervix cancer (HeLa) and human fibroblast (HF) by COBRA (Figure 1b). The gene discussed is CLDN11; the disease is melanoma.