PNLIP and obesity due to melanocortin 4 receptor deficiency: Recently, the molecular interactions between EGCG analogs and pancreatic lipase have been described by Wang et al. These authors confirmed that EGCG had different effect on activity, conformation, thermodynamics and kinetics of pancreatic lipase suggesting that EGCG could contribute to the development of natural effective pancreatic lipase inhibitors to prevent human obesity [79].