Indeed, ISG products such as PKR [34], Mx [35], p53 [36], ISG20 [37], Ifit2/ISG54 [38], IFITM3 [39], Tetherin [39], Ch25h [40] and ProMyelocytic Leukemia (PML) [41,42,43] have been reported to confer resistance to VSV infection (Figure 1). Here, IFIT2 is linked to leukemia.