TGFB1 and neoplasm: M2 TAMs produce VEGF, FGF chemokines IL-17, IL-23, or TGF-β that contribute to stimulation of vascular endothelial cell proliferation, release of MMPs, which degrade the vascular basement membrane and induce sprouting, migration of endothelial cells into the tumor and this process further leads to tube formation and maturation of new microvessel.