NFKB1 and acute respiratory distress syndrome: In addition, we found that the LPS-induced cell apoptosis was attenuated by administration of an antioxidant and NF-κB inhibitor through down-regulation of Fas/FasL signaling, indicating that the protective role of kallistatin in LPS-induced ALI and lung epithelial cell apoptosis is mediated by decreased ROS generation and NF-κB activation, subsequently down-regulating Fas/FasL signaling.