TIMP1 and Insulin resistance: TIMP-1 is a matrix metalloproteinase crucial for the extracellular reorganization which has been described as a negative regulator of adipogenesis; in vivo, TIMP1 leads to enlargement of adipocytes in state of overnutrition which might be responsible of systemic fatty acid overload, hepatic lipid accumulation and insulin resistance in TIMP-1 injected mice48.