In contrast, lung tumor sublines H1339 ctrl/H1339 HSF-1 KD and EPLC-272H ctrl/EPLC-272H HSF-1 KD with identical mHsp70 levels did not show significant differences in apoptosis, as determined by active Caspase 3/7 and Annexin V positivity under non-irradiated (sham) and irradiated (6 Gy) conditions (Fig. 4e and f), although an increased apoptosis was observed following irradiation at 6 Gy in both tumor cell systems. The gene discussed is CASP3; the disease is neoplasm.