RNF13 and melanoma: Transwell experiments showed that either nonconditioned media or the conditioned media generated by culturing WT lung slices only slightly stimulated the invasion of B16F10 cells from the upper to the lower chamber, whereas the conditioned media obtained from the culture of RNF13-KO lung slices dramatically stimulated the invasion of B16F10 melanoma cells (Fig. 5B and 5D).