INS and diabetes mellitus: 2012). As in the case of sensory neurons previously mentioned, there appears to be a link between insulin deficiency and mitochondrial function. Franko and colleagues showed that, in murine STZ-induced diabetes, mitochondrial function was negatively impacted by means of a reduced transcription of mitochondrial genes mediated via decreased PGC-1α expression which was not evident in a type 2 or insulin-resistant model (Franko et al. 2012).