The aim of the present study was to evaluate the role of subtype EP2 receptor signaling for development of anorexia in tumor-bearing animals since genetic knockout studies could not verify a role of other PGE receptor candidates as EP1, EP3, or EP4, in mediating the prostaglandin-induced anorexic response of the tumor-bearing host (Wang et al. Here, PTGER3 is linked to neoplasm.