CXCL12 and Obesity: Additionally, mice lacking CXCR2 show resistance to the onset of obesity-induced disorders of glucose metabolism, and a recent study found that SDF-1/CXCL12, which is secreted from hypertrophic adipocytes, recruits macrophages via CXCR4, which is the receptor of SDF-1/CXCL12, during obesity [43].