Additionally, mice lacking CXCR2 show resistance to the onset of obesity-induced disorders of glucose metabolism, and a recent study found that SDF-1/CXCL12, which is secreted from hypertrophic adipocytes, recruits macrophages via CXCR4, which is the receptor of SDF-1/CXCL12, during obesity [43]. This evidence concerns the gene CXCR4 and obesity disorder.