In the present study the PCR Array data indicate that T-cadherin expression in B16F10 melanoma cells results in the activation of genes of such angiogenic inhibitors as procollagen type XVIIIα1 (a precursor of the angiogenesis inhibitor endostatin) [15] and chromogranin A (a precursor of angiogenesis inhibitor vasostatin-1) [16] which have not been detected in control cells. This evidence concerns the gene CHGA and melanoma.