KRAS and colon carcinoma: While treatment with the GLI transcription activity inhibitor GANT61 down-regulated expression of the FEN1 gene related to NHEJ in colon carcinoma cells [56], Wu et al. found that the SMO inhibitor cyclopamine inhibited expression of radiation-induced DNA DSB repair proteins such as DNA-PKcs and Ku70 (NHEJ) in human pancreatic cancer cell lines (KRAS-wt Colo357 and KRAS-mutant SW1990).