MOG and acute disseminated encephalomyelitis: More recently, with the use of different cell-based assays, anti-MOG antibodies could be identified in a subgroup of pediatric ADEM (acute disseminated encephalomyelitis), CIS (clinically isolated syndrome), or MS [57,58,59,60,61,62,63,64,65,66,67,68,69] and were shown to correlate with the disease course [63,70].