In contrast with these results, we did not observe a significant decrease in M1 marker genes, including MMP9, NOS2, CCL2, IL-6 and ARG2, in granuloma FCMs compared with NFMs, although MMP13 and NF-κB1 levels, which are also M1-related genes [24,37,38], were decreased. Here, MMP9 is linked to Granuloma.