Our findings differ from those of Yeh et al who found that polymorphisms D58E59 and D58K59 were associated with significantly reduced IL-8 induction when introduced into CagL of the gastric cancer-associated H. pylori strain Hp1033 compared to the Y58E59 polymorphism carried by the isogenic wild-type [10]. Here, CXCL8 is linked to gastric cancer.