Taken together, we propose that the invasive and metastatic ability of cancer cells may be induced by the reduction of ROS, which can be achieved by in vivo intrinsic gene dysregulation, such as the silencing of TXNIP as demonstrated here or of FBP1 as reported recently [27] or by in vitro extrinsic factors, such as antioxidant NAC treatment. This evidence concerns the gene TXNIP and cancer.