Moreover, TXNIP was reduced, whereas miR-373, HIF1α and TWIST were increased in primary breast cancers and lymph node metastases compared to the adjacent normal breast tissues (Figure 6B, 6C, Supplementary Figure S5), and these alterations in miR-373, TXNIP, HIF1α and TWIST were also observed in patients with LN-positive primary breast cancers compared to LN-negative primary cancers (Figure 6D, 6E; Supplementary Figure S5, S6). The gene discussed is TWIST1; the disease is breast cancer.