The critical role for IFN-γ and STAT1 in restricting Toxoplasma, taken together with our finding that TLX is induced in the brain during infection and can regulate IFN-γ-dependent expression of molecules such as CXCL9, CXCL10, GBP4, and GBP5, prompted us to examine whether TLX impacted infection or pathogenesis. The gene discussed is GBP5; the disease is infection.