Both of them are regulators of RyR2[15] and mutations in both triadin and calmodulin have been associated with catecholaminergic polymorphic ventricular tachycardia, a rare familial arrhythmogenic disorder characterized by maligant ventricular arrhythmias and increased risk of SCD[16, 17]. The gene discussed is TRDN; the disease is Schnyder corneal dystrophy.