A proteomics comparison that analyzed an EBV-associated NPC cell line (C666–1) and normal nasopharyngeal cell line (NP69) showed that ANXA2 was downregulated in the NPC cell line and found that cytoplasmic staining, complete and incomplete membrane staining, and both cytoplasmic and membrane staining were all lost in clinical tissues [19]. The gene discussed is ANXA2; the disease is nasopharyngeal carcinoma.