LKB1 loss selectively sensitises human cell lines and genetically engineered mouse models (GEMMs) of NSCLC as well as mouse MC38 colon cancer and Lewis lung carcinoma cell lines by inducing energetic stress and metabolic catastrophe that resulted in cellular apoptosis (Algire et al, 2011; Shackelford et al, 2013b) (Figure 2). The gene discussed is STK11; the disease is non-small cell lung carcinoma.