PIK3CA and neoplasm: Of interest, both rapamycin and the dual PI3K/mTOR inhibitor BEZ235 inhibited tumour growth in an Lkb1/Pten-deficient GEMM of endometrial cancer agreeing with a previous study that showed that single-therapy rapamycin effectively reduced tumour burden in Lkb1-deficient GEMM of endometrial ADC (Contreras et al, 2010; Cheng et al, 2014).