STK11 and large cell carcinoma: LKB1 mutations were detected in approximately 20–30% of lung adenocarcinoma (ADC), 70% of mucinous bronchiolar ADC and to a lesser extent in squamous and large cell carcinomas (Sanchez-Cespedes et al, 2002; Ji et al, 2007; Osoegawa et al, 2011; Wilkerson et al, 2012).