Mice that lack Nrf1 in the liver develop non-alcoholic fatty liver disease (NAFLD) that progresses to non-alcoholic steatohepatitis (NASH), and Nrf2−/− mice develop NASH on a high-fat diet (Xu et al., 2005; Okada et al., 2013; Tsujita et al., 2014). The gene discussed is NRF1; the disease is metabolic dysfunction-associated steatotic liver disease.