A similar map for the interactions of the 25 down-regulated proteins in urinary exosomes from prostate cancer patients could indicate a central role of the tyrosine kinase Lck, phosphatidylinositol-specific phospholipase C and ESCRT-0 proteins STAM1/2 for signalling events abolished in exosomes from prostatic cancer tissue (Supplemental Fig S5B). This evidence concerns the gene STAM and prostate cancer.