As we showed that Nrp-1 and PlexinD1 are the functional receptors for Sema3C and since these two receptors are strongly upregulated in ROP (Oh et al, 2002; Fukushima et al, 2011), we also confirmed the increased expression of both receptors during physiological angiogenesis (Supplementary Fig S7A) and on pre-retinal tufts during OIR (Fig 7B and C, Supplementary Fig S7B). The gene discussed is NRP1; the disease is retinopathy of prematurity.