Lastly, losartan reduced the expression of TNF-α in RDEB paws in line with a preliminary suggestion that TNF-α is involved in the pathophysiology of RDEB (Gubinelli et al, 2010), and additionally, TNF-receptor signaling has recently been implicated to promote formation of wound-induced SCCs (Hoste et al, 2015). This evidence concerns the gene TNF and recessive dystrophic epidermolysis bullosa.