TGFB1 and recessive dystrophic epidermolysis bullosa: The present study concentrated in elucidation of the molecular mechanisms and changes the concept of RDEB as a cutaneous mechanobullous disorder into that of a systemic fibrotic disease and shows that restraining TGF-β activity markedly improves the phenotype at tissue, cellular, and molecular levels, that is, diminishes inflammation, excessive ECM accumulation, and tissue stiffness.