BCR and HIV infectious disease: The network visualizations (figure 1) and BCR statistics (figures 2 and 3) reported here indicate that the BCR clone size distribution during early HIV infection is much less skewed than that observed for B-cell cancers [8], meaning that HIV-specific clonal expansions may be difficult to detect from bulk antibody samples without some form of functional filtering or screening (e.g. antigen-specific cell sorting or isolation of plasmablasts [30]).