Given that myosin interfilament spacing did not differ between the groups, we speculated that LV contractile dysfunction driven by impaired CB dynamics in early diabetes might be attributed to a reduction in the activity of myosin accessory proteins, myosin light chain-2 (MLC-2) or cardiac myosin binding protein-C (MyBP-C), which meticulously regulate myosin head extension on a beat-to-beat basis [9–13]. The gene discussed is MYBPC3; the disease is diabetes mellitus.