VEGFA and neoplasm: Myeloid-derived suppressor cells (MDSCs), previously called immature myeloid cells [21] or myeloid suppressor cells[22–24], is a major contributor in facilitating tumor-induced immune suppression, induced by a variety of factors including vascular endothelial growth factor [11], GM-CSF[25, 26], and pro-inflammation cytokines such as IL-1 [27, 28].