DIS3 and neoplasm: A recent amplicon sequencing study identified three hotspot mutations (R780, D488 and E665) within the RNB domain of DIS3 and investigations in HEK-293 cells indicate that the R780K mutation leads to a lower proliferation rate compared to the WT cell line, suggesting a loss-of-function phenotype which would classify DIS3 as a tumour-suppressor gene.