MMP2 and cancer: Recent studies have shown that AP-2α can regulate cell function by targeting related cancer genes such as the ErbB2 proto-oncogene, the cell-cycle control gene cyclin-dependent kinase inhibitor 1A (CDKNI1A), and the cell adhesion and invasion genes matrix metallopeptidase 2 (MMP-2), matrix metalloproteinase 9 (MMP-9) and pseudoautosomal-1 (PAR-1) [12].