By combining the results of these studies, researchers may identify landscape marks in the EWS OMIC atlas explaining some of the mechanisms behind the behavior of Ewing sarcoma with the aim to identify new, targeted therapeutic targets These targets can be validated by combining functional studies and testing In addition, this might shed light on the cell of origin and secondary events necessary for tumor formation and changes that are related to a more therapy resistant or more aggressive phenotype. Here, EWSR1 is linked to Ewing sarcoma.