EWSR1 and Ewing sarcoma: An open chromatin structure at the enhancer and super-enhancer sites, as identified by Tomazou et al. [32], may be needed for the transforming effect of a EWSR1-ETS fusion protein in the development of Ewing sarcoma and if a more closed chromatin state was present an EWSR1-ETS translocation would lead to different effects or cell death.