For example, we have previously shown that certain SLE susceptibility loci demonstrate stronger associations with anti-dsDNA autoantibody production than SLE itself [3], and that genetic variation in the major histocompatibility complex (MHC) is more strongly associated with anti-SSA/Ro and anti-SSB/La autoantibody production than other SLE manifestations [4]. The gene discussed is CALR; the disease is systemic lupus erythematosus.