IRF5 and Autoimmunity: As part of an ongoing scientific collaboration in the context of therapeutic and toxicity predictive value related to IFNα in E1697 we have completed our testing of IRF-5 polymorphisms and high-throughput SNP analysis of a wide array of genes with previously documented immunologic roles (Immunochip) to evaluate potential predictors of autoimmunity that may be associated with immunotherapeutic benefit.