Electrostatically driven protein membrane association involving PIP2 residues has been already observed in other systems, like for Pten tumor supressor's binding to the plasma membrane (Stansfeld et al., 2009) or for syntaxin-1A clustering to PI(4,5)P2 areas on the membrane (van den Bogaart et al., 2011). Here, STX1A is linked to neoplasm.