IFNL3 and Hepatic fibrosis: On multivariate logistic regression analysis, HCV genotype 1b (OR 3.4, 95% CI 1.20–9.51) and IL28B genotype CC at rs12979860 (OR 7.4, 95% CI 1.70–32.08) remained significantly associated with SVR12 to triple therapy, whereas advanced liver fibrosis (OR 0.3, 95% CI 0.12–0.89) and a history of previous partial or null-response to PEG-IFN/RBV treatment (OR 0.3, 95% CI 0.12–0.94) remained significantly associated with failure to achieve SVR12 to triple therapy (Table 3).