Takashi et al. (2012) described a mutant alleles in some family groups and he mentioned specifically his finding with the clinical features of patients with B-RAF mutations V600EB-RAF mutations were found both in children with granuloma of bones or isolated skin disease, and in infants with early-onset multi-organ disease and he mentioned that the somatic mutation in some patients confirmed despite the mother with the same allele, was in good health and did not report a personal history of LCH. Here, BRAF is linked to Langerhans cell histiocytosis.