LPL is a potential target for treatment of CAD because LPL gene variants are involved in multiple genes and environmental risk factors associated with CAD.10,11 One of the most desirable candidate genes is LPL gene that may be explain some of the lipid and lipoprotein abnormalities faced in numerous cases of CAD.12 In this study, we presented the results on polymorphisms of the LPL gene, HindIII and S447X and their association with CAD and environmental risk factors including smoking, hypertension, hyperlipidemia, TG and HDL-C levels. The gene discussed is LPL; the disease is hyperlipidemia.