To determine if the effects on the transcriptome after specifically inhibiting CBP are different than the effects after inhibiting both CBP and p300, we treated HCT116 colon cancer cells with 0.05% DMSO, 10 uM ICG-001, or 10 uM C646 for 12 and 96 h. This evidence concerns the gene EP300 and malignant colon neoplasm.