A putative association between HLA-A*74:01 and a favorable CD4:CD8 ratio is rather consistent with previous reports based on analyses of HIV-1 acquisition, VL and/or CD4 count after HIV-1 infection (Koehler et al., 2010; Leslie et al., 2010; Tang et al., 2010; Lazaryan et al., 2011; Peterson et al., 2013). The gene discussed is MLC1; the disease is HIV-1 infection.