The third locus, CELSR2–PSRC1 [associated with decreased serum levels of LDL (5)] spatially connects to SORT1 (1p13.3), which is implicated in LDL and triglyceride metabolism (13); NOTCH2 (1p13-p11), which is involved in pancreas development (13) and associated with T2D (1); BCAR3 (1p22.1), which is in the insulin signaling pathway (13); and region 21q22.3, which includes DNMT3L (regulator of methyltransferases, embryonic development, and imprinting), B3GALT5 (implicated in pancreatic cancer) (13), and ABCG1 (cellular lipid homeostasis). The gene discussed is INS; the disease is type 2 diabetes mellitus.