RNF214 and cardiovascular disorder: This locus contains rs174535 (chr 11: 61551356), which connects spatially with several loci that are known diabetes risk factors: FADS3 (11q12-q13.1), which regulates desaturation of fatty acids and is clustered with FADS1 and FADS2; RNF214 (11q23.3), which is associated with cardiovascular disease in women with migraines; and USP6 (17p13), which is involved in cell migration and division.