The third locus, CELSR2–PSRC1 [associated with decreased serum levels of LDL (5)] spatially connects to SORT1 (1p13.3), which is implicated in LDL and triglyceride metabolism (13); NOTCH2 (1p13-p11), which is involved in pancreas development (13) and associated with T2D (1); BCAR3 (1p22.1), which is in the insulin signaling pathway (13); and region 21q22.3, which includes DNMT3L (regulator of methyltransferases, embryonic development, and imprinting), B3GALT5 (implicated in pancreatic cancer) (13), and ABCG1 (cellular lipid homeostasis). This evidence concerns the gene CELSR2 and type 2 diabetes mellitus.