Therefore, despite the fact that no direct link has been captured between the IGF2BP2 locus on chromosome 3 and the HNF1A locus on chromosome 12, the shared connection with GRM5 and additional connections to loci that have been previously associated with T2D is consistent with these SNPs associating with a larger hub that links different genes that contribute to T2D. Here, GRM5 is linked to type 2 diabetes mellitus.