HIF1A and B-cell chronic lymphocytic leukemia: Also, GLUT1 represents one of the HIF-1α target genes (Majumder et al., 2004) that can be down-regulated by inhibitors of the mTOR signaling pathway in AML cells (Zeng et al., 2007), or specific HIF-1 inhibitors in B-cell CLL/lymphoma-2 (BCL2; Yonekura et al., 2013).