Therefore, we built a Pearson correlation matrix including our candidate genes (Cmya5, Mctp1, Rxrg, and Tnr), genes commonly coexpressed with MCTP1 and RXRG or TNR and RXRG within the mental disorders and CNS Diseases annotations (Supplementary Tables 3, 6), and 10 genes containing SNPs which have been strongly associated with BD (SLC6A4, BDNF, DAOA, DTNBP1, NRG1, DISC1, CACNA1C, ANK3, ODZ4, COMT; Szczepankiewicz, 2013; Mühleisen et al., 2014). This evidence concerns the gene COMT and mental disorder.