While it has been well documented that respiration rates are lowered in ALS (Kawamata and Manfredi, 2010; Cozzolino and Carri, 2012; Peixoto et al., 2013) even well before physical pathologies develop (Browne et al., 2006), this meta-analysis supports the assertion that this phenomenon is a trend that, at least in the high-copy SOD1 G93A transgenic mouse model, is present since birth. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.