Even though many forms of intellectual disability are thought to be due to changes in synaptic transmission (Swiech et al., 2008; Stornetta and Zhu, 2011; Levenga and Willemsen, 2012), our results thus show that changes in mTOR or Ras signaling do not result in ubiquitous in vivo changes in synaptic transmission. This evidence concerns the gene MTOR and Intellectual disability.