When we further stratified patients by TNM stage, we found that most of the patients in TNM stage I and II were TMPRSS4 negative (247 of 352), while half of the patients in TNM stage III were TMPRSS4 positive (p = 0.006, Table 2), suggesting the expression of TMPRSS4 was significantly correlated with tumor staging. The gene discussed is TMPRSS4; the disease is neoplasm.