In this study, despite the risk factors such as vascular invasion and tumor number, multivariate analysis reveled that TMPRSS4 expression was an independent risk factor for both OS (p < 0.001, HR: 2.20, 95% CI: 1.66–2.90) and recurrence (p < 0.001, HR: 1.95, 95% CI: 1.45–2.63) after curative resection (Table 1). Here, TMPRSS4 is linked to neoplasm.