SNCA and Parkinson disease: Most of our understanding of this pathway has come not only from in vitro studies of aggregation-prone proteins, including amyloid-beta (seen in AD) and alpha-synuclein (seen in PD) but also from studies of globular proteins, including human lysozyme, superoxide dismutase 1, transthyretin and the acylphosphatase from the archaea Sulfolobus solfataricus (reviewed in [17, 125, 126, 146, 147]).