NANOG is a homeodomain-containing transcription factor essential for establishing pluripotency18 with a known function in TPC maintenance in many adult cancers.19 It has already been characterized as a GLI target gene in neural stem cells, medulloblastoma and glioblastoma neurospheres.20, 21 Therefore, we chose to further study its role in ERMS. This evidence concerns the gene NANOG and cancer.